Brothers Seth gecko (George Clooney) Y Richard Gecko (Quentin Tarantino) flee justice after committing a robbery and killing several Texas Rangers. In order to avoid the controls at the border with Mexico, they kidnap the preacher Jacob (Harvey Keitel) and her two children (Juliette Lewis Y Ernest liu), also appropriating his motor home.
Together with them they cross the border and head to a secluded joint of motorcyclists and truckers, called The curled tit, in which the Gecko they must wait for their contact, who will arrive at dawn.
After a fight, the brothers Gecko They are attacked by the doorman of the bar and two other men, who are brutally murdered. The blood in the place awakens the thirst of the bar’s employees, all of them vampires, one of whom is Satanic Pandemonium (Salma Hayek), an exotic dancer. And there’s still a whole night to go …