At the beginning of the thirties, he began to work in the company of Enrique Muiño Y Elijah Alippi, where he met the actress Chela Lamb, who became his first wife.
In 1933 he made his film debut in ¡Tango !, the first sound film in Argentina where he shared credits with Pepe Arias, Freedom Lamarque, Azucena Maizani Y Tita Merello.
On the radio it was Felipe, a character who made him known as a good-natured Buenosairean, this role gave him great success and some time later he was taken to the small screen by Channel 13, where he was next to Tato Bores, Alberto Olmedo, Pepe biondi, Jose Marrone, Carlos Bala, Dringue Farías and Juan Carlos Altavista.
He continued in the theater with When elves hunt partridges, a production that was later taken to the big screen, where he met and married the young actress Malvina Pastorino. This film made him more popular during the golden age of Argentine cinema and later he participated in the series of hotels, lodging with the cicada is not a bug.
Sandrini made his last appearances in traditional family films that were in charge of Enrique Carreras and in the filming of How beautiful my family is from Palito Ortega, the July 5, 1980 at 75 years of age.